‘Less Survivable Cancers Taskforce’ reports UK has low survival rates compared with other developed countries for cancers including liver, oesophageal, pancreatic and stomach
The UK has some of the worst cancer survival rates in the developed world, according to new research. Analysis of international data by the Less Survivable Cancers Taskforce found that five-year survival rates for lung, liver, brain, oesophageal, pancreatic and stomach cancers in the UK are worse than in most comparable countries. On average, just 16% of […]
Significant rises in bowel cancer in under 50s reported in the journal Annals of Oncology
The rate at which people under the age of 50 in the UK are dying from bowel cancer is on course to rise by a third this year, according to projections that experts say are alarming and stem from a surge in obesity, poor diets and physical inactivity. Death rates among those aged 25 to […]
SpiraCheck attended the Emerging Medtech Summit 2024
A Comparison of DESI-MS and LC-MS for the Lipidomic Profiling of Human Cancer Tissue
In this study, we make a direct comparison between desorption electrospray ionization-mass spectrometry (DESI-MS) and ultraperformance liquid chromatography-electrospray ionization-mass spectrometry (UPLC-ESI-MS) platforms for the profiling of glycerophospholipid (GPL) species in esophageal cancer tissue.
Diagnostic Metabolomic Blood Tests for Endoluminal Gastrointestinal Cancer–A Systematic Review and Assessment of Quality
Advances in analytics have resulted in metabolomic blood tests being developed for the detection of cancer. This systematic review aims to assess the diagnostic accuracy of blood-based metabolomic biomarkers for endoluminal gastrointestinal (GI) cancer. Using endoscopic diagnosis as a reference standard, methodologic and reporting quality was assessed using validated tools, in addition to pathway-based informatics […]
Sequential simulation (SqS) of clinical pathways: a tool for public and patient engagement in point-of-care diagnostics
Public and patient engagement (PPE) is fundamental to healthcare research. To facilitate effective engagement in novel point-of-care tests (POCTs), the test and downstream consequences of the result need to be considered.
Impact of oral cleansing strategies on exhaled volatile organic compound levels
The analysis of volatile organic compounds (VOCs) within exhaled breath potentially offers a non-invasive method for the detection and surveillance of human disease. Oral contamination of exhaled breath may influence the detection of systemic VOCs relevant to human disease. This study aims to assess the impact of oral cleansing strategies on exhaled VOC levels in […]
De Novo Lipogenesis Alters the Phospholipidome of Esophageal Adenocarcinoma
The incidence of esophageal adenocarcinoma is rising, survival remains poor, and new tools to improve early diagnosis and precise treatment are needed. Cancer phospholipidomes quantified with mass spectrometry imaging (MSI) can support objective diagnosis in minutes using a routine frozen tissue section.
Accuracy and Methodologic Challenges of Volatile Organic Compound-Based Exhaled Breath Tests for Cancer Diagnosis: A Systematic Review and Meta-analysis
The detection and quantification of volatile organic compounds (VOCs) within exhaled breath have evolved gradually for the diagnosis of cancer. The overall diagnostic accuracy of proposed tests remains unknown.
Perioperative changes in exhaled nitric oxide during oesophagectomy
Oesophagectomy is a major surgical procedure, associated with high rates of postoperative cardiopulmonary morbidity, that is in part due to the frequent requirement for periods of intraoperative one-lung ventilation (OLV).
